Welcome to the Michigan Center for Integrative Research in Critical Care (MCIRCC). We hope you take time to thoroughly explore our web site and take note of this highly unique multidisciplinary translational research consortium dedicated to the field of critical illness and injury. Not well understood by the public and even government, critical illness and injury exact a tremendous societal and economic toll.

The Michigan Center for Integrative Research in Critical Care is one of the world’s first comprehensive research enterprises devoted to improving the care of the victim of critical illness and injury. MCIRCC is pursuing this unique mission by creating an innovative multidisciplinary research infrastructure designed to catalyze the translation of scientific discovery to the multiple interrelated disease platforms of critical illness and injury involving all age groups and patient populations. MCIRCC will serve as the scientific home and platform for basic scientists, engineers, clinical investigators, inventors and entrepreneurs interested in the care of patients with life-threatening acute illness and injury.

MCIRCC is Accomplishing its Mission by:

  • Creating a highly coordinated, collaborative, and multidisciplinary research infrastructure within the University that provides strong sustained links between clinical, basic, information and engineering sciences.
  • Facilitating the application of new knowledge by prioritizing research aimed at rapid translation from bench to bedside that will result in novel prevention, diagnostic, and therapeutic strategies for critical illness and injury in all age groups and populations.
  • Promoting partnerships with industry as well as local, state, and federal agencies to enhance the discovery and implementation of diagnostic and therapeutic modalities.
  • Developing new intellectual property and small business startups to facilitate translation of new technologies.
  • Serving as an educational and training resource to promote the future of critical care at the local, state, national, and international level.

What makes us unique is our vision to be comprehensive and integrated in our approach, which spans all major clinical entities in critical illness and injury ranging from adults to children and trauma to medical, and couples them with deliberate engineering and applied basic science expertise from one of the world’s most powerful research and educational institutions. We are also comprehensive in our approach, which seeks to research care of the critically ill and injured victim across the spectrum of the system from the site where the illness or injury was incurred to each level of care through the health system. This ranges from the ambulance and even battlefield to the emergency department to the operating room to intensive care unit and to the rehabilitation and home setting. A weakness at any of these critical links greatly reduces the chance that our patients will experience a full recovery.

Our research motto is Restoring Life Through Integration, Innovation, and Collaboration. With over 100 scientist and clinicians spread throughout 30 departments, divisions and centers across the University of Michigan it’s easy to envision the power of such a collaboration and the unique innovations that can result. Because of the incredible complexities of critical illness and injury, MCIRCC stresses the use of integrated approaches, which leverage the use of advanced engineering systems methods to tackle problems in critical care long believed to be intractable. Please explore our Faculty page to examine the incredible breadth and depth of talent at the University, which allow for such an approach.

As evidence of this, the NIH Funded U.S. Critical Illness and Injury Trials (USCIIT) group identified the following fundamental gaps in critical care medicine. These include:

  • Fragmented nature of care for the critically ill and injured, across time (prehospital, inpatient, rehab), across domains (ED, OR, ICU, floor), specialties (physicians, nurses, therapists, nutritionists, scientists, engineers), and geography.
  • Lack of a mechanism for investigator-government-community interaction to drive multicenter studies, strategic planning, and best practice
  • Educational curricula and training opportunities for clinical research and trial design in the ICU
  • Paucity of university and hospital support for critical illness and injury research, which is typically dispersed across multiple departments

As you navigate our website and more importantly, interact with us, you will find that MCIRCC will lead by example to confront these fundamental gaps head on to create the next generation approaches to the critically ill and injured.  MCIRCC is committed to leveraging each and every discovery across the entire spectrum of critical care.

You will also note several unique programs within MCIRCC such as one focused on combat casualty care. MCIRCC is developing one of the largest civilian led research efforts in the county in the area of battlefield casualty care.  Advances made in this area funded by the Department of Defense are now having an impact on our civilian care of critically ill and injured patients such as newborns.  This is yet another outstanding characteristic of our organization: The insight and ability to leverage every discovery across the entire spectrum of critical care and beyond.

The spectrum of engineering, scientific and computational sciences used to form such solutions includes fields such as materials science and nanotechnology, biomedical signal and image processing, unique approaches to bioinformatics and data mining, systems biology, and advanced preclinical biologic model development and experimentation. The marriage of these engineering, medical and applied sciences are creating a number of commercialized sensors, systems, and computational methodologies with the promise of saving lives.

The University of Michigan Health System with its University and C.S. Mott Children’s Hospitals are renown for their care of the most critically ill and injured patients and for the rapid translation of discoveries to the bedside for improving patient care.

We also pride ourselves in partnering with other centers of excellence within University of Michigan as well as with local and national businesses. Please visit our partners page to learn more about these centers and partnerships. We are always interested in developing new partnerships with industry and in collaborating with other academic and community health care centers to develop solutions for our patients.

If you would like for information about MCIRCC or would like to explore a partnership, please don’t hesitate to contact us. We look forward to learning more about you and your needs.

Kevin R. Ward, MD
Director: MCIRCC
Professor of Emergency Medicine


Shuichi Takayama, PhD
Associate Director: MCIRCC
Professor & Associate Chair, Technology Transfer, Department of Biomedical Engineering
Professor, Macromolecular Science and Engineering Program
Investigator, Biointerfaces Institute



Janene Centurione, MBA
Managing Director: MCIRCC