mcircc announces 2014 grand challenge funding awards

MCIRCC Announces 2014 Grand Challenge Funding Awards

First inaugural program funding will accelerate 6 innovative sepsis solutions for potential commercialization

Back in January, nearly 50 MCIRCC members attended the first annual MCIRCC Critical Care Grand Challenge Symposium targeting sepsis, an incredibly complex public health problem that represents more than one million cases annually, a mortality rate up to 40-percent, and the single largest hospital treatment cost in the United States. The two-day educational symposium concluded with the release of a request for proposal to support high-impact sepsis projects up to $100,000 for milestone driven research guided by co-principal investigators from the U-M Medical School and College of Engineering. Funding for the MCIRCC Grand Challenge was provided by the Deans of the Medical School and College of Engineering as well as the Department of Emergency Medicine. MCIRCC received a total of 14 proposals and following a rigorous evaluation process by an external panel of experts, shortlisted eight projects to work hand-in-hand with assigned mentors and other U-M support groups to prepare a detailed project plan and budget that addressed real-world challenges and practical uses for their solutions. On July 16, these eight teams pitched their final proposals to an evaluation committee – comprised of ICU physicians, members of the U-M Office of Technology Transfer and Fast Forward Medical Innovation, and industry and venture capital professionals – for final funding decisions. Based on the depth and breadth of the science and the apparent commercialization potential in these proposals, the evaluation committee recommended funding the following six projects at $50,000 each: 1. Chiroplasmic Nanorod-PCR (NR-PCR) for Rapid Determination of Bacteremia and Antibiotic Resistance in Sepsis, J. Scott VanEpps, MD, PhD (U-M Medical School) & Nicholas A. Kotov, PhD (U-M College of Engineering) 2. Development of a Sepsis Point-of-Care (POC) Platform Utilizing Redox Measurements with Integrated Protein Markers of Sepsis as a Bedside Biomarker for Sepsis, Severity of Septic Shock, and as a Gauge for Resuscitation Endpoints, Rodney Daniels, MD (U-M Medical School) & Shuichi Takayama, PhD (U-M College of Engineering) 3. Real-Time Ultrasound Local Lung Ventilation Measurement, Jonathan Rubin, MD, PhD (U-M Medical School) & Cheri Deng, PhD (U-M College of Engineering) 4. Sepsis Endotheliopathy Assessment Panel, Rodney Daniels, MD (U-M Medical School) & Xudong (Sherman) Fan, PhD (U-M College of Engineering) 5. Immunotherapy and Immuno-phenotyping for Treatment of Sepsis, Jean Nemzek, DVM, MS (U-M Medical School) & Jianping Fu, PhD (U-M College of Engineering) 6. Non-Invasive Portable System for Continuous Monitoring of Sepsis, Kayvan Najarian, PhD (U-M Medical School) & Kenn Oldham, PhD (U-M College of Engineering) Moving forward, these six funded teams will work with MCIRCC’s Commercialization Coach to achieve their key milestones and ultimately the next phase in the product development roadmap. MCIRCC would like to take this opportunity to congratulate each of the funded teams identified above and to thank all 14 teams for their hard work, creative thought and support of this important initiative. It took all of you to make MCIRCC’s first annual Critical Care Grand Challenge a success! For more information, please contact Janene Centurione at or 734-647-4751.

airstrip provide mobile monitoring and early patient warning technology using ibm’s real time

AirStrip to Provide Mobile Monitoring and Early Patient Warning Technology Using IBM’s Real-Time Analytics

U-M Center for Integrative Research in Critical Care to Pioneer New Patient Analytics Solutions

ARMONK, NY and SAN ANTONIO, Texas – 22 October, 2014 – AirStrip® and IBM (NSYE:IBM) today announced that AirStrip will work to develop a mobile monitoring solution to help clinicians predict declining health in acute and critically ill patients. IBM will provide the streaming analytics technology which allows AirStrip’s solution to use data from numerous data sources in real time. The new solution, being co-developed by AirStrip with the U-M Center for Integrative Research in Critical Care, will bring together data from electronic medical records, body sensors and other sources with predictive analytics to create an AirStrip mobile Acute Care Early Warning System (mACEWS), that ultimately could be used to provide critical health insights to doctors’ mobile devices. The system will be designed by AirStrip and the U-M Center for Integrative Research in Critical Care (MCIRCC) to help hospitals better manage acutely ill patients. MCIRCC will pioneer the application of this technology with AirStrip by developing the advanced analytics and testing its ability to identify and predict a serious and unexpected complication called hemodynamic decompensation, one of the most common causes of death for critically ill or injured patients. MCIRCC researchers anticipate that the resulting solution may provide the clinical decision support tool that enables clinicians to identify patient risk factors for early intervention. Early intervention can enhance critical care delivery, improve patient outcomes, and reduce ICU admissions (according to source). If successful, this clinical decision support tool created by AirStrip and MCIRCC could transition beyond critical care into comprehensive hospital-to-home care models. “By mining multiple data streams, looking at real-time analytics and applying our adaptive learning algorithms, we believe we can come up with new computed vital signs that are even more valuable than the signals we’re monitoring today,” said Kevin Ward, M.D., MCIRCC’s executive director and professor of Emergency Medicine, U-M Medical School. “Ultimately, we believe that clinical decision support solutions coupled with our analytic methodologies could help us improve patient outcomes while reducing overall costs in the healthcare system.” The AirStrip mACEWS system will collect and translate structured and unstructured data via the AirStrip ONE® platform, and deliver real-time analytics on that data using IBM® InfoSphere® Streams, an advanced analytic platform that can be used in most any industry and with multiple types of data, that allows customer-developed applications to quickly ingest, analyze and correlate millions of data points per second as they arrive from thousands of real-time sources. The AirStrip mACEWS system’s resulting predictive care insights would then be ready for consumption by clinicians who use AirStrip’s mobile applications on Apple, Android and Windows devices. “Predictive analytics have the potential to provide clinicians the ability to see and take action on much more of the potentially available data on their patients, and course-correct sooner when a complication presents,” said Sean Hogan, vice president and general manager of IBM Healthcare. A tool such as the one being developed by AirStrip could also be applied to patients being monitored both inside and outside the hospital to detect clinical deterioration from chronic obstructive pulmonary disease (COPD), diabetes, congestive heart failure, or other chronic diseases. “With its ability to assimilate vast amounts of data and provide real time analytics, IBM effectively complements AirStrip’s established leadership position in mobile interoperability,” said Alan Portela, CEO of AirStrip. “Our products hold the promise of measurably improving the clinical, operational and financial bottom lines in healthcare, delivering innovation that can measurably strengthen patient care while addressing real-world challenges faced by providers.”

About AirStrip
AirStrip® ( provides a complete, vendor- and data source-agnostic enterprise-wide clinical mobility solution, which enables clinicians to improve the health of individuals and populations. With deep clinical expertise and strong roots in mobile technology and data integration, AirStrip is empowering leading health systems globally as the industry continues to evolve at a rapid pace. Based in San Antonio, Texas, AirStrip allows health systems to unlock the full potential of their existing technology investments with a complete mobility solution that provides access to critical patient data across the care continuum. AirStrip is backed by investments from Dignity Health, St. Joseph Health, the Gary and Mary West Health Investment Fund, Sequoia Capital, Qualcomm, Inc., Leerink Partners, Hospital Corporation of America (HCA) and the Wellcome Trust. AirStrip’s base of visionary clients includes HCA, Texas Health Resources, Tenet Healthcare, Dignity Health, St. Joseph Health and Ardent Health Services.
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The University of Michigan Center for Integrative Research in Critical Care (MCIRCC) is one of the world’s first comprehensive research enterprises devoted to transforming critical care medicine by accelerating science and moving it from bench to bedside. To do this, MCIRCC brings together integrative teams comprised of world-class U-M scientists, clinicians, and engineers with industry partners and funding sources to develop and deploy cutting-edge solutions that elevate the care, outcomes, and quality of life of critically ill and injured patients and their families. Learn more at
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Holli Haswell, IBM External Relations 720-396-5485 Kara Gavin, MCIRCC Media Relations 734-764-2220

pioneering solutions

Pioneering Solutions

The First Annual MCIRCC Grand Challenge Targets Sepsis

The Michigan Center for Integrative Research in Critical Care (MCIRCC) hosted its first annual Grand Challenge event over the course of two, half-day sessions on January 24 and 25.  Nearly 50 MCIRCC members attended this inaugural event, braving blizzard conditions to attend the program all in the fight against sepsis.

“As a young organization gaining its foothold, this level of member representation at our first Grand Challenge event is exciting and encouraging as we strive to push research beyond the idea stage for real-world impact,” stated MCIRCC’s Managing Director Janene Centurione.

The Grand Challenge targets the most pressing problems in critical care by leveraging integrated science teams to engage, develop and deliver technological solutions to key critical care health problems.  For its inaugural event, MCIRCC zeroed in on sepsis because of its complexity, impact, and far-reaching implications across the critical care spectrum.

With more than a million cases each year in the U.S. and 250,000 deaths annually, sepsis poses a serious public health problem. U-M Pediatric Intensivist and MCIRCC member, Timothy Cornell describes it as, “…one of the most common situations that bring both previously healthy and patients with prior diseases (i.e. cancer) into our intensive care unit. Sepsis is either the primary issue causing critical illness or can be the result of treatment for other conditions that result in immunosuppression.”

Day 1 of the Grand Challenge program examined the complex science, incidence, economic and non-economic costs, diagnosis and treatment challenges attributed to sepsis; potential models for new therapeutics, diagnostics, devices or digital health solutions to support the septic patient and healthcare provider were also presented. Day 2 introduced MCIRCC members to internal U-M resources and entrepreneurial fundamentals to support the development of solutions suitable for future commercialization.

The two-day program ended on a high note, with the release of the MCIRCC Grand Challenge Funding Opportunity that will support high-impact proposals up to $100,000 per project for milestone driven research to take place over the next 18 months. Taking a unique “team science” approach, each Proposal must have a joint PI from the University of Michigan’s Medical School and the College of Engineering.

Even if a research team doesn’t receive funding this time around, the learning from the Grand Challenge could give their solution the jumpstart that it needs. MCIRCC Director Dr. Kevin Ward noted, “The gift that might keep giving from the Grand Challenge is not just the technologies that come out of it and are funded, but the collaborations that result, the fact that we are able to educate people working in this area to think differently about potential projects and funding opportunities.”

For more information on becoming a MCIRCC member, or the Grand Challenge, please contact Janene Centurione at